"Use of Cell-Based Assays for Translational Research"

Carmelita Frondoza, Department of Orthopaedic Surgery, Johns Hopkins University

There is a growing trend toward the use of cell-based assays in translational research. Cell-based assays are designed to study complex biological pathways within the physiological environment of specific types of cells. The success of cell-based assays has been supported by significant advances in the retrieval and propagation of cells for in vitro studies. The success of cell-based assays has also been facilitated by the availability of transfection technologies for studies of the behavior of specific biological molecules. Cell-based assays provide the opportunity to study entire pathways of interest and target multiple intervention points. They have become an important tool in discovery of therapeutic agents, in tissue engineering and development of products that may promote health as well as manage disease.

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